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Microwave-Assisted Amination from Aryl Triflates without Base and Catalyst

Gang Xu and Yan-Guang Wang*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, Email: orgwygzju.edu.cn

G. Xu, Y.-G. Wang, Org. Lett., 2004, 6, 985-987.

DOI: 10.1021/ol049963j (free Supporting Information)


Abstract

Aryl triflates substituted with both electron-poor and electron-rich groups are effectively converted to the corresponding anilines under microwave irradiation in 1-methyl-2-pyridone (NMP) without base and catalyst. It is noteworthy that halogenated aryl triflates chemoselectively afford halogenated anilines.


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Key Words

Aryl Triflates, Amination, Microwave Synthesis


ID: J54-Y2004-020