Ruthenium-Catalyzed Oxidative Cleavage of Alkynes to Carboxylic Acids
Dan Yang,* Fei Chen, Ze-Min Dong, and Dan-Wei Zhang
*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China, Email: yangdanhku.hk
D. Yang, F. Chen, Z.-M. Dong, D.-W. Zhang, J. Org. Chem., 2004, 69, 209-212.
DOI: 10.1021/jo0357925 (free Supporting Information)
An efficient method for the oxidative cleavage of internal and terminal alkynes to carboxylic acids using a combination of RuO2/Oxone/NaHCO3 in a CH3CN/H2O/EtOAc solvent system is described. Various alkynes, regardless of their electron density, were oxidized to carboxylic acids in excellent yield.
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D. Yang, C. Zhang, J. Org. Chem., 2001, 66, 4814-4818.