Palladium and Raney Nickel Catalyzed Methanolic Cleavage of Stable Borane-Amine Complexes
Michel Couturier,* John L. Tucker, Brian M. Andresen, Pascal Dubé and Joanna T. Negri
*Process Research and Development, Pfizer Global Research and Development,
Eastern Point Road, P.O. Box 8013, Groton, Connecticut 06340-8013, Email:
michel_a_couturier
groton.pfizer.com
M. Couturier, J. L. Tucker, B. M. Andresen, P. Dube, J. T. Negri, Org. Lett., 2001, 3, 465-467.
DOI: 10.1021/ol006969+
Abstract
Palladium and Raney nickel catalyze the methanolysis of strongly complexed borane-amine adducts. The method is applicable to primary, secondary, tertiary, and aromatic amines, and the mildness of the reaction conditions allows preservation of otherwise labile functional groups.
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Key Words
Methanolysis, Borane-Amine Adducts, Borane, Deoxygenations
ID: J54-Y2001-420
