Organic Chemistry Portal

Abstracts

Search:

Montmorillonite KSF clay catalyzed one-pot synthesis of α-aminonitriles

J. S. Yadav*, B. V. Subba Reddy, B. Eeshwaraiah and M. Srinivas

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: yadavpubiict.res.in

J. S. Yadav, B. V. S. Reddy, B. Eeshwaraiah, M. Srinivas, Tetrahedron, 2004, 60, 1767-1771.

DOI: 10.1021/ol026273b (free Supporting Information)


Abstract

Aryl imines, formed in situ from aldehydes and amines undergo mild nucleophilic addition with trimethylsilyl cyanide on the surface of montmorillonite KSF clay to afford the corresponding α-aminonitriles in excellent yields. The solid acid can be recovered and recycled in subsequent reactions with a gradual decrease of activity.


see article for more examples



Key Words

Solid acids, Aryl imines, Trimethylsilyl cyanide, α-Aminonitriles, Strecker Synthesis


ID: J72-Y2004-280