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Copper-Catalyzed Synthesis of 1,3-Enynes

Craig G. Bates, Pranorm Saejueng and D. Venkataraman*

*Department of Chemistry, University of Massachusetts-Amherst, 710 North Pleasant Street, Amherst, Massachusetts 01003, Email:

C. G. Bates, P. Saejueng, D. Venkataraman, Org. Lett., 2004, 6, 1441-1444.

DOI: 10.1021/ol049706e (free Supporting Information)


A copper(I)-catalyzed coupling of alkynes with vinyl iodides affords various enynes in good to excellent yields, tolerates a variety of functional groups, and does not require the use of expensive additives.

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Key Words

1,3-Enynes, Copper-Catalysis

ID: J54-Y2004-350