A Straightforward and Mild Synthesis of Functionalized 3-Alkynoates
Andrés Suárez, Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
MA 02139, USA, Email: gcf
mit.edu
A. Suárez, G. C. Fu, Angew. Chem. Int. Ed., 2004, 43, 3580-3582.
DOI: 10.1002/anie.200454070 (free Supporting Information)
Abstract
A general, inexpensive, copper-catalyzed coupling of terminal alkynes with diazo compounds provides ready access to 3-alkynoates. This reaction proceeds efficiently under nonbasic conditions at room temperature and tolerates various functional groups.
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Key Words
alkynes, carboxylic compounds, copper, diazo compounds, homogeneous catalysis
ID: J06-Y2004-490
