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A Straightforward and Mild Synthesis of Functionalized 3-Alkynoates

Andrés Suárez, Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email: gcfmit.edu

A. Suárez, G. C. Fu, Angew. Chem. Int. Ed., 2004, 43, 3580-3582.

DOI: 10.1002/anie.200454070 (free Supporting Information)


Abstract

A general, inexpensive, copper-catalyzed coupling of terminal alkynes with diazo compounds provides ready access to 3-alkynoates. This reaction proceeds efficiently under nonbasic conditions at room temperature and tolerates various functional groups.

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Key Words

alkynes, carboxylic compounds, copper, diazo compounds, homogeneous catalysis


ID: J06-Y2004-490