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Organotin Hydride-Catalyzed Conjugate Reduction of α,β-Unsaturated Ketones

David S. Hays, Matthias Scholl, Gregory C.Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email: gcfmit.edu

D. S. Hays, M. Scholl, G. C.Fu, J. Org. Chem., 1996, 61, 6751-6752.

DOI: 10.1021/jo960846e (free Supporting Information)


Abstract

An organotin hydride-catalyzed, silicon hydride-mediated method for effecting the conjugate reduction of α,β-unsaturated ketones was developed.

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proposed mechanism



Key Words

1,4-Reduction, Tributyltin hydride, Phenylsilane


ID: J42-Y1996-290