Highly Efficient Pd-Catalyzed Carbonylative Cross-Coupling Reactions with Tetraorganoindates

Sung Wook Lee, Kooyeon Lee, Dong Seomoon, Sundae Kim, Hyunseok Kim, Hyun Kim, Eunkyong Shim, Miae Lee, Seokju Lee, Misook Kim, and Phil Ho Lee*

*Department of Chemistry, Kangwon National University, Chunchon 200-701, Republic of Korea, Email: phleekangwon.ac.kr

S. W. Lee, K. Lee, D. Seomoon, S. Kim, H. Kim, H. Kim, E. Shim, M. Lee, J. Org. Chem., 2004, 69, 4852-4855.

DOI: 10.1021/jo0495790

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Abstract

Tetraorganoindates, which are easily prepared from 1 eq. of InCl₃ and 4 eq. of organometallics, could be employed as effective nucleophilic cross-coupling partners in Pd-catalyzed carbonylative cross-coupling reactions with a variety of electrophiles under a carbon monoxide atmosphere. The present method gave unsymmetrical ketones in good yields.

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Key Words

Ketones, Aryl ketones, Palladium, Catalysis

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ID: J42-Y2004-580