Enantioselective organocatalytic aldehyde-aldehyde cross-aldol couplings. The broad utility of α-thioacetal aldehydes
R. Ian Storer and David W. C. MacMillan*
*Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd;, Pasadena, CA 91125, USA, Email: dmacmillcaltech.edu
R. I. Storer, D. W. C. MacMillan, Tetrahedron, 2004, 60, 7705-7714.
An asymmetric proline catalyzed cross-aldol reaction with α-thioacetal aldehydes as electrophilic partners has been developed. Anti-aldol adducts are produced with high levels of reaction efficiency as well as diastereo- and enantiocontrol with a broad range of aldehyde and ketone donors.
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