A general and efficient method for the palladium-catalyzed cross-coupling of thiols and secondary phosphines
Miki Murata and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, 77
Massachusetts Ave. Bldg 18-305, Cambridge, MA 02139, USA, Email:
sbuchwal
mit.edu
M. Murata, S. L. Buchwald, Tetrahedron, 2004, 60, 7397-7403.
DOI: 10.1016/j.tet.2004.05.044
Abstract
A versatile and efficient Pd(OAc)2/1,1'-bis(diisopropylphosphino)ferrocene-catalyzed cross-coupling of thiols with aryl halides was developed. Aryl bromides and chlorides can be coupled to aliphatic and aromatic thiols - the widest substrate scope of any reported to date. This catalyst system also enables the coupling of secondary phosphines with aryl halides.
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Key Words
Palladium catalysis, Thiol cross-coupling, Phosphine cross-coupling
ID: J72-Y2004-690
