Palladium charcoal-catalyzed deprotection of O-allylphenols
Miyuki Ishizaki, Makoto Yamada, Shin-ichi Watanabe, Osamu Hoshino, Kiyoshi Nishitani, Maiko Hayashida, Atsuko Tanaka and Hiroshi Hara*
*Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641,
Yamazaki, Noda-shi, Chiba 278-8510, Japan, Email: h.hara
rs.noda.tus.ac.jp
M. Ishizaki, M. Yamada, S.-I. Watanabe, O. Hoshino, K. Nishitani, M. Hayashida, A. Tanaka, H. Hara, Tetrahedron, 2004, 60, 7973-7981.
DOI: 10.1016/j.tet.2004.05.097
Abstract
Allyl aryl ethers can be easily cleaved by the use of 10% Pd/C under mild and basic conditions. The present reaction would involve a SET process rather than a π-allyl-palladium complex. The scope and limitation of this new deprotective methodology are also described.
see article for more examples
Key Words
Allyl aryl ethers, Allyl Ethers, Deprotection, Palladium charcoal, SET process
ID: J72-Y2004-710
