One-Pot Homolytic Aromatic Substitutions/HWE Olefinations under Microwave Conditions for the Formation of a Small Oxindole Library
Antje Teichert, Katja Jantos, Klaus Harms and Armido Studer*
*Fachbereich Chemie, Philipps-Universität Marburg, 35032 Marburg, Germany.
Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster,
Corrensstrasse 40, 48149 Münster, Germany, Email: studer
uni-muenster.de
A. Teichert, K. Jantos, K. Harms, A. Studer, Org. Lett., 2004, 6, 3477-3480.
DOI: 10.1021/ol048759t (free Supporting Information)
Abstract
A small library of α,β-unsaturated oxindoles was prepared by an efficient microwave-assisted one-pot sequence comprising an aromatic substitution followed by an ionic Horner-Wadsworth-Emmons olefination.
Preparation of Phosphonates
Preparation of Alkoxyamines
see article for more examples
Key Words
Oxindoles, Wittig-Horner Reaction, Microwave Synthesis
ID: J54-Y2004-780
