Cp2Fe(PR2)2PdCl2 (R = i-Pr, t-Bu) Complexes as Air-Stable Catalysts for Challenging Suzuki Coupling Reactions

Thomas J. Colacot* and Helene A. Shea

*Catalysis & Chiral Technologies, Johnson Matthey, 2001 Nolte Drive, West Deptford, New Jersey 08066, Email: colactjjmusa.com

T. J. Colacot, H. A. Shea, Org. Lett., 2004, 6, 3731-3734.

DOI: 10.1021/ol048598t (free Supporting Information)

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Abstract

The use of Cp₂Fe(PR₂)₂PdCl₂ (R: i-Pr and t-Bu) in Suzuki coupling reactions were illustrated using a high throughput screening approach. The di-tbpfPdCl₂ catalyst was shown to be the more active catalyst for unactivated and sterically challenging aryl chlorides. Comparison studies using commercial catalysts were also done for selected cases to demonstrate the superior activities of di-tbpfPdCl₂ and di-isoppfPdCl₂.

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Key Words

Suzuki Coupling

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ID: J54-Y2004-840