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C1-Symmetric Sulfoximines as Ligands in Copper-Catalyzed Asymmetric Mukaiyama-Type Aldol Reactions

Martin Langner and Carsten Bolm*

*Institut für Organische Chemie der Rheinisch-Westfälischen Technischen Hochschule Aachen, Landoltweg 1, 52056 Aachen, Germany, Email: carsten.bolmoc.rwth-aachen.de

M. Langner, C. Bolm, Angew. Chem. Int. Ed., 2004, 43, 5984-5987.

DOI: 10.1002/anie.200460953 (free Supporting Information)


Abstract

The synthesis of new C1-symmetric benzene-bridged aminosulfoximines is described.  These aminosulfoximines are capable of serving as efficient ligands in copper-catalyzed enantioselective Mukaiyama-type aldol reactions.

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Key Words

aldol reaction, asymmetric catalysis, copper, N ligands, sulfoximines, Mukaiyama Aldol Addition, β-hydroxy carbonyl compounds


ID: J06-Y2004-860