Enantioselective Cu-Catalyzed Conjugate Addition of Diethylzinc to Acyclic Aliphatic Enones

Andrew P. Duncan and James L. Leighton*

*Department of Chemistry, Columbia University, New York, New York 10027, Email: leightonchem.columbia.edu

A. P. Duncan, J. L. Leighton, Org. Lett., 2004, 6, 4117-4119.

DOI: 10.1021/ol048191o (free Supporting Information)

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Abstract

A new P-chiral phosphine bis(sulfonamide) ligand allows the Cu-catalyzed enantioselective conjugate addition of Et₂Zn to various acyclic aliphatic enones with excellent levels of enantioselectivity (90-95% ee) at ambient temperature.

see article for more examples

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Zusammenfassung

Ein neuer, P-chiraler Phosphinbis(sulfonamid)-Ligand erlaubt die Cu-katalysierte, konjugate Addition von Et₂Zn an unterschiedliche, acyclische, aliphatische Enone mit ausgezeichneter Enantioselektivität bei Raumtemperatur.

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Key Words

Conjugate Addition, Copper Catalysis

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Schlüsselworte

Konjugate Addition, Kupfer-Katalyse

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ID: J54-Y2004-950