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Stereochemical Control of the Passerini Reaction

Peter R. Andreana, Chang C. Liu and Stuart L. Schreiber*

*Howard Hughes Medical Institute, Center for Chemical Methodology and Library Development (CMLD-HU) & Broad Institute of Harvard and MIT, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email: stuart_schreiberharvard.edu

P. R. Andreana, C. C. Liu, S. L. Schreiber, Org. Lett., 2004, 6, 4231-4233.

DOI: 10.1021/ol0482893 (free Supporting Information)


Abstract

A catalytic asymmetric Passerini reaction using a tridentate indan (pybox) Cu(II) Lewis acid complex with substrates capable of bidentate coordination has been achieved.

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Key Words

Passerini Reaction, Multicomponent Reactions


ID: J54-Y2004-960