Synthesis of Primary Amines by the Electrophilic Amination of Grignard Reagents with 1,3-Dioxolan-2-one O-Sulfonyloxime
Mitsuru Kitamura, Takahiro Suga, Shunsuke Chiba and Koichi Narasaka*
*Department of Chemistry, Graduate School of Science, The University of
Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:
narasaka
chem.s.u-tokyo.ac.jp
M. Kitamura, T. Suga, S. Chiba, K. Narasaka, Org. Lett., 2004, 6, 4619-4621.
DOI: 10.1021/ol0479951 (free Supporting Information)
Abstract
The electrophilic amination of Grignard reagents with 4,4,5,5-tetramethyl-1,3-dioxolan-2-one O-phenylsulfonyloxime followed by acidic hydrolysis of the resulting imines gave primary amines.
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Zusammenfassung
Die electrophile Aminierung von Grignard-Reagenzien mit 4,4,5,5-Tetramethyl-1,3-dioxolan-2-on-O-phenylsulfonyloxim führte nach saurer Hydrolyse des Zwischenproduktes (ein Imin) zu primären Aminen.
Key Words
electrophilic amination
Schlüsselworte
Electrophile Aminierung
ID: J54-Y2004-1070
