Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions
Alexander J. A. Cobb, David M. Shaw, Deborah A. Longbottom, Johan B. Gold and Steven V. Ley*
*Department of Chemistry, University of Cambridge, Lensfield Road,
Cambridge, UK CB2 1EW, Email: svl1000
cam.ac.uk
A. J. A. Cobb, D. M. Shaw, D. A. Longbottom, J. B. Gold, S. V. Ley, Org. Biomol. Chem., 2005, 3, 84-96.
DOI: 10.1039/b414742a
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Abstract
Proline-derived organocatalysts have been synthesised and applied to the asymmetric Mannich, nitro-Michael and aldol reactions to give superior results than those of proline-catalysed reactions.
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Key Words
Mannich reaction, Organocatalysis
ID: J52-Y2005-050
