Catalytic Reductive Alkylation of Secondary Amine with Aldehyde and Silane by an Iridium Compound
Tomoya Mizuta, Satoshi Sakaguchi and Yasutaka Ishii*
*Department of Applied Chemistry, Faculty of Engineering & High Technology Research Center, Kansai University, Suita, Osaka 564-8680, Japan, Email: ishiiipcku.kansai-u.ac.jp
T. Mizuta, S. Sakaguchi, Y. Ishii, J. Org. Chem., 2005, 70, 2195-2199.
DOI: 10.1021/jo0481708 (free Supporting Information)
An efficient methodology for the reductive alkylation of secondary amines with aldehydes and Et3SiH using an iridium complex as a catalyst has been developed. In addition, a cheaper, easy-to-handle, and environmentally friendly reducing reagent such as polymethylhydrosiloxane (PMHS) in place of Et3SiH was also useful.
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