New General Sulfinylating Process for Asymmetric Synthesis of Enantiopure Sulfinates and Sulfoxides
Bruce Z. Lu,* Fuqiang Jin, Yongda Zhang, Xinhe Wu, Stephen A. Wald and Chris H. Senanayake
*Chemical Process R&D, Sepracor, Inc., 84 Waterford Drive, Marlborough,
Massachusetts 01752, Email: zlu
rdg.boehringer-ingelheim.com
B. Z. Lu, F. Jin, Y. Zhang, X. Wu, S. A. Wald, C. H. Senanayake, Org. Lett., 2005, 7, 1465-1468.
DOI: 10.1021/ol0501020 (free Supporting Information)
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Abstract
Several sulfoxides have been synthesized in excellent enantiopurities and
high yields using sulfinyl transfer agents based on the cinchona alkaloids
quinine and quinidine.
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Key Words
ID: J54-Y2005-370
