Copper-Catalyzed Enantioselective Conjugate Addition of Grignard Reagents to α,β-Unsaturated Esters
Fernando López, Syuzanna R. Harutyunyan, Auke Meetsma, Adriaan J. Minnaard, Ben L. Feringa*
*Department of Organic Chemistry and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands, Email: b.l.feringarug.nl
F. Lopez, S. R. Harutyunyan, A. Meetsma, A. J. Minnaard, B. L. Feringa, Angew. Chem. Int. Ed., 2005, 44, 2752-2756.
DOI: 10.1002/anie.200500317
Abstract
Inexpensive and readily available Grignard reagents and stable dinuclear Cu complexes can be used for the catalytic enantioselective conjugate addition to simple acyclic α,β-unsaturated methyl esters providing β-substituted chiral esters in good yields and with excellent enantioselectivities.
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Key Words
asymmetric catalysis, conjugate addition, copper, enantioselectivity, Grignard reagents
ID: J06-Y2005-450