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Ni(II)-Catalyzed Conia-Ene Reaction of 1,3-Dicarbonyl Compounds with Alkynes

Qiang Gao, Bao-Fu Zheng, Jin-Heng Li and Dan Yang*

*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China, Email: yangdanhku.hk

Q. Gao, B.-F. Zheng, J.-H. Li, D. Yang, Org. Lett., 2005, 7, 2185-2188.

DOI: 10.1021/ol050532q (free Supporting Information)


Abstract

A Ni(II)-catalyzed Conia-ene reaction of  various acetylenic 1,3-dicarbonyl compounds has been discovered. The reaction gave mono- and bicyclic olefinic cyclopentantes in good yields in the presence of Ni(acac)2 and Yb(OTf)3.

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Key Words

Conia-Ene Reactions, Active methylenes, Cyclopentanes


ID: J54-Y2005-550