Ru-Catalyzed Anti-Markovnikov Addition of Amides to Alkynes: A Regio- and Stereoselective Synthesis of Enamides
Lukas J. Gooßen*, Jan E. Rauhaus, Guojun Deng
*Institut für Chemie - Organische Chemie, TU Kaiserslautern,
Erwin-Schrödinger-Straße, Geb. 54, 67663 Kaiserslautern Email: goossen
chemie.uni-kl.de
L. J. Goossen, J. E. Rauhaus, G. Deng, Angew. Chem. Int. Ed., 2005, 44, 4042-4045.
DOI: 10.1002/anie.200462844 (free Supporting Information)
Abstract
A mild, ruthenium-catalyzed anti-Markovnikov addition of secondary amides, anilides, lactames, ureas, bislactames, and carbamates to terminal alkynes has been developped. Two complementary protocols provide either the E or the Z isomers.
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Key Words
alkynes, amides, carbamates, ureas, enamides, homogeneous catalysis, hydroamidation, ruthenium
ID: J06-Y2005-510
