An Efficient and Practical Procedure for the Synthesis of 4-Substituted Coumarins

Surya K. De*, Richard A. Gibbs

*Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA, Email: skd125pharmacy.purdue.edu

S. K. De, R. A. Gibbs, Synthesis, 2005, 1231-1233.

DOI: 10.1055/s-2005-865282

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Abstract

BiCl₃ is used as an efficient catalyst in the Pechmann condensation reaction of phenols with β-keto esters leading to the formation of coumarin derivatives in excellent yields under solvent-free conditions.

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Key Words

phenols, β-keto ester, Pechmann reaction, bismuth(III) chloride, coumarin

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ID: J66-Y2005-760