An Efficient and Practical Procedure for the Synthesis of 4-Substituted Coumarins
Surya K. De*, Richard A. Gibbs
*Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA, Email: skd125pharmacy.purdue.edu
S. K. De, R. A. Gibbs, Synthesis, 2005, 1231-1233.
BiCl3 is used as an efficient catalyst in the Pechmann condensation reaction of phenols with β-keto esters leading to the formation of coumarin derivatives in excellent yields under solvent-free conditions.
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phenols, β-keto ester, Pechmann reaction, bismuth(III) chloride, coumarin