In Situ Generation of o-Iodoxybenzoic Acid (IBX) and the Catalytic Use of It in Oxidation Reactions in the Presence of Oxone as a Co-oxidant
Arun P. Thottumkara, Michael S. Bowsher and Thottumkara K. Vinod*
*Department of Chemistry, Western Illinois University, Macomb, Illinois 61455, Email: mftkvwiu.edu
A. P. Thottumkara, M. S. Bowsher, T. K. Vinod, Org. Lett., 2005, 7, 2933-2936.
DOI: 10.1021/ol050875o (free Supporting Information)
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Catalytic use of o-iodoxybenzoic acid (IBX) in the presence of Oxone as a co-oxidant is demonstrated for the oxidation of primary and secondary alcohols. In addition, the in situ oxidation of 2-iodosobenzoic acid (IBA) and even commercially available 2-iodobenzoic acid (2IBAcid) by Oxone to IBX allows the use of these less hazardous reagents, in place of potentially explosive IBX, as catalytic oxidants.