Simple Method for the Esterification of Carboxylic Acids

Bernhard Neises and Wolfgang Steglich*

*Institut für Organische Chemie und Biochemie der Universität, Gerhard-Domagk-Strasse 1, D-5300 Bonn (Germany)

B. Neises, W. Steglich, Angew. Chem. Int. Ed., 1978, 17, 522-524.

DOI: 10.1002/anie.197805221

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Abstract

The addition of 3-10 mol-% DMAP accelerates the DCC-activated esterification of carboxylic acids with alcohols and thiols to such an extent that formation of side products is suppressed and even sterically demanding esters are formed in good yields at room temperature.

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Key Words

Steglich Esterification, esters, thioesters

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ID: J06-Y1978-040