Phosphine-Free Palladium Acetate Catalyzed Suzuki Reaction in Water
Leifang Liu, Yuhong Zhang* and Yanguang Wang
*Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China, Email:
yhzhang
zjuem.zju.edu.cn
L. Liu, Y. Zhang, Y. Wang, J. Org. Chem., 2005, 70, 6122-6125.
DOI: 10.1021/jo050724z
Abstract
Pd(OAc)2 is an
extremely active catalyst for the Suzuki reaction of aryl iodides and bromides in a mixture of water and poly(ethylene glycol)
at 50°C.
Products are
readily isolated by the extraction with diethyl ether, and Pd(OAc)2-PEG can
be reused without significant loss in activity.
see article for more examples
S. Shi, Y. Zhang, J. Org. Chem., 2007, 72, 5927-5930.
Key Words
Suzuki Coupling, Green Chemistry
ID: J42-Y2005-970
