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Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydro­pyrimidin-2-(1H)-ones under Solvent-Free Conditions

Surya K. De*, Richard A. Gibbs

*Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA, Email:

S. K. De, R. A. Gibbs, Synthesis, 2005, 1748-1750.

DOI: 10.1055/s-2005-869899


Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.

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Key Words

pyrimidinones, ruthenium, aldehyde, Biginelli reaction, solvent-free conditions, heterocycles, multicomponent reactions

ID: J66-Y2005-980