A Straightforward Synthesis of Ynones by Reaction of Dimethylalkynylaluminum Reagents with Acid Chlorides
Baomin Wang, Martine Bonin and Laurent Micouin*
*Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à
l'Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques
4, av de l'Observatoire, 75270 Paris Cedex 06, France, Email:
laurent.micouin
univ-paris5.fr
B. Wang, M. Bonin, L. Micouin, J. Org. Chem., 2005, 70, 6126-6128.
DOI: 10.1021/jo050760y (free Supporting Information)
Abstract
Alkynyldimethylaluminum reagents react efficiently with various aromatic and
aliphatic acid chlorides without any transition metal as a catalyst to give
ynones in good yields.
see article for more examples
Key Words
ID: J42-Y2005-1000
