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The First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd-N-Heterocyclic Carbene (NHC) Catalyst

Niloufar Hadei, Eric Assen B. Kantchev, Christopher J. O'Brien and Michael G. Organ*

*Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada, Email: organyorku.ca

N. Hadei, E. A. B. Kantchev, C. J. O'Brien, M. G. Organ, Org. Lett., 2005, 7, 3805-3807.

DOI: 10.1021/ol0514909 (free Supporting Information)


Abstract

A Pd-NHC catalytic system has been developed, that is capable of cross-coupling various unactivated, primary bromides and alkyl organozinc reagents in high yield at room temperature.

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Key Words

Negishi Coupling, Alkanes


Room-Temperature Negishi Cross-Coupling of Unactivated Alkyl Bromides with Alkyl Organozinc Reagents Utilizing a Pd/N-Heterocyclic Carbene Catalyst

N. Hadei, E. A. B. Kantchev, C. J. O'Brien, M. G. Organ, J. Org. Chem., 2005, 7, 8503-8507.

DOI: 10.1021/jo051304c (free Supporting Information)


ID: J54-Y2005-1190