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Zn/CuI-Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides

Matthew M. Zhao,* Chuanxing Qu, and Joseph E. Lynch

Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, Email: matthew_zhaomerck.com

M. M. Zhao, C. Qu, J. E. Lynch, J. Org. Chem., 2005, 70, 6944-6947.

DOI: 10.1021/jo050500g


Abstract

A Zn/CuI-mediated coupling of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides is described. Formamide is a superior solvent for obtaining high yields.

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Key Words

Sulfones, Sulfonamides


ID: J42-Y2005-1200