RuCl3 in Poly(ethylene glycol): A Highly Efficient and Recyclable Catalyst for the Conjugate Addition of Nitrogen and Sulfur Nucleophiles
Huaxing Zhang, Yuhong Zhang*, Leifang Liu, Hailiang Xu, Yanguang Wang
*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, Email: yhzhangzjuem.zju.edu.cn
H. Zhang, Y. Zhang, L. Liu, H. Xu, Y. Wang, Synthesis, 2005, 2129-2136.
A versatile RuCl3-catalyzed 1,4-conjugate addition of primary, secondary and aromatic amines, thiols, and carbamates to α,β-unsaturated compounds in poly(ethylene glycol) (PEG) provides the desired β-substituted carbonyls in high yields. RuCl3-PEG offers low sensitivity toward moisture and oxygen, high tolerance of different functional groups, and efficient recyclability.
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