Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp*Ir Complex

Ken-ichi Fujita, Chiho Asai, Tetsuhiro Yamaguchi, Fumihiro Hanasaka and Ryohei Yamaguchi*

*Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan, Email: yamakagaku.mbox.media.kyoto-u.ac.jp

K.-I. Fujita, C. Asai, T. Yamaguchi, F. Hanasaka, R. Yamaguchi, Org. Lett., 2005, 7, 4017-4019.

DOI: 10.1021/ol051517o (free Supporting Information)

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Abstract

β-Alkylation of various secondary alcohols with primary alcohols has been achieved in the presence of [Cp*IrCl₂]₂ (Cp* = pentamethylcyclopentadienyl) catalyst and a base. This reaction proceeds in good to excellent yield via successive hydrogen-transfer reactions and aldol condensation.

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Key Words

Alcohols

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ID: J54-Y2005-1350