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A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction

Uli Kazmaier* and Stefanie Ackermann

*Institut für Organische Chemie, Universität des Saarlandes, D-66123 Saarbrücken, Germany, Email: u.kazmaiermx.uni-saarland.de

U. Kazmaier, S. Ackermann, Org. Biomol. Chem., 2005, 3, 3184-3187.

DOI: 10.1039/b507028g


Abstract

Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation.

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Key Words

Ugi Reaction, Microwave assisted synthesis, Thioamides, Thiazoles


ID: J52-Y2005-1390