A straightforward approach towards thiazoles and endothiopeptides via Ugi reaction
Uli Kazmaier* and Stefanie Ackermann
*Institut für Organische Chemie, Universität des Saarlandes, D-66123
Saarbrücken, Germany, Email:
u.kazmaier
mx.uni-saarland.de
U. Kazmaier, S. Ackermann, Org. Biomol. Chem., 2005, 3, 3184-3187.
DOI: 10.1039/b507028g
Abstract
Endothiopeptides can easily be obtained via Ugi reaction using thio acids as acid components. If isonitriles with an acetal group are applied, the endothiopeptides can directly be converted into thiazoles using TMSCl-NaI under microwave irradiation.
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Key Words
Ugi Reaction, Microwave assisted synthesis, Thioamides, Thiazoles
ID: J52-Y2005-1390
