Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones
Yonggui Chi and Samuel H. Gellman*
*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706,
Email: gellman
chem.wisc.edu
Y. Chi, S. H. Gellman, Org. Lett., 2005, 7, 4253-4256.
DOI: 10.1021/ol0517729 (free Supporting Information)
Abstract
An intermolecular Michael addition of simple aldehydes to nonactivated enones with high enantioselectivities is catalyzed by 5 mol-% diphenylprolinol methyl ether.
see article for more reactions
Key Words
Michael Addition, 1,4-Addition, organocatalysis
ID: J54-Y2005-1500
