Organic Chemistry Portal

Abstracts

Search:

Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

Yonggui Chi and Samuel H. Gellman*

*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, Email: gellmanchem.wisc.edu

Y. Chi, S. H. Gellman, Org. Lett., 2005, 7, 4253-4256.

DOI: 10.1021/ol0517729 (free Supporting Information)


Abstract

An intermolecular Michael addition of simple aldehydes to nonactivated enones with high enantioselectivities is catalyzed by 5 mol-% diphenylprolinol methyl ether.

see article for more reactions



Key Words

Michael Addition, 1,5-Diketones, organocatalysis


ID: J54-Y2005-1500