Categories: Medicinal Chemistry >> Molecular Modelling

An Introduction to Medicinal Chemistry

Description

This lively, highly illustrated text provides undergraduate and postgraduate students with an accessible introduction to medicinal chemistry. It covers basic principles and background, and then describes the general tactics and strategies involved in developing an effective drug. Through the use of numerous examples it highlights both the difficulties faced by the medicinal chemist and the great potential of rational drug design. The second edition has five new chapters and is updated to include recent advances in the field.

Editoral Review

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Contents

GENERAL PRINCIPLES
1 Drugs and the medicinal chemist
2 The why and the wherefore
3 Protein structure
4 Drug action at enzymes
5 Drug action at receptors
6 Receptor
7 Nucleic acids
8 Drug discovery and drug development
9 Drug design - drug/target interactions
10 Pharmacokinetics
11 Quantitative structure-activity relationships (QSAR)
12 Combinatorial synthesis
13 Computers in medicinal chemistry
TOPICS
14 Antibacterial agents
15 The peripheral nervous system-cholinergics, anticholinergics, and anticholinesterases
16 The adrenergic nervous system
17 The opium analgesics
18 Cimetidine - a rational approach to drug design
Appendices
Glossary
Further reading
Index