Categories: Medicinal Chemistry
Molecules and Medicine
E. J. Corey, László Kürti, Barbara Czakó
Softcover, 272 Pages
First Edition, 2007
Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. Beautifully illustrated and presented in full colour, this book delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now used in modern medicine.
With focus on the most important and commonly used medicines such as anti-clotting agents, antibiotics, Viagra and anti-malarial and antidepressant drugs, coverage includes the condition it treats, the summary of its industrial development, the year put into practice, the biological target for the medicine, the human proteins related to the disease, the metabolism or action of the condition treated, and interacting side effects and related drugs. Diagrams revealing the shape and structure of molecular make-up for each medicine accompany the text. Interspersed where appropriate, can be found background sections such as a brief survey of immunology, to help guide the readers understanding.
Molecules and Medicine is directed at a broad audience, and tries to explain drugs and diseases in an understandable way. Thus, the book even contains an introduction on the make-up of molecules, where the fundamentals of structure and bonding are explained. This introduction is nicely done and contains attractive pictures, but students will know these principles from other books, and I doubt if a reader without any chemical training will be able to follow them at the pace they are presented. This chapter is much too short, and the concepts of medicinal chemistry are not mentioned. Thus, the reader will miss out on understanding the biochemical principles and important molecular properties that are responsible for the intermolecular interactions with a target; these latter are far more conducive to an understanding of drug development than isolated observations on orbitals and three-dimensional biological macromolecules. The untrained reader might have more interest in the various stages of drug development, but will find nothing about this in the book, and so will never appreciate the efforts and costs that must be expended for each of the drugs described in the following chapters to reach commercialization.
However, readers who have the benefit of chemical, biochemical and medicinal
chemical training from the corresponding textbooks should certainly take a look
at this book, since the subsequent chapters are recommendable on the strength of
their brief and readable illustrations of the important targets and drugs. The
biochemistry behind specific diseases is explained schematically, drugs are
displayed as structures and 3D models, and for some molecules a depiction of the
inhibited enzyme is also provided. Here, the reader will find citations to
supplemental literature on interesting diseases, introductory explanations and a
multitude of commercial drugs; on this basis, the book can be recommended to
obtain a general overview of current research trends as well as an introduction
to a specific topic.
UNDERSTANDING STRUCTURAL DIAGRAMS OF ORGANIC MOLECULES.
SOME COMMON MOLECULES.
PROTEINS AND THREE-DIMENSIONAL PROTEIN STRUCTURE
INFLAMMATORY, CARDIOVASCULAR AND METABOLIC DISEASES
Acetylsalicylic acid (Aspirin™)
How Do Anti-Inflammatory Drugs Work?.
Other Eicosanoids in Inflammation
An Overview of Inflammation
ANTIASTHMATIC AND ANTIALLERGIC AGENTS
Fluticasone Propionate (Flovent™).
Montelukast Sodium (Singulair™).Tiotropium Bromide (Spiriva™).
TYPE 2 DIABETES
An Overview of Metabolic Syndrome
ANTIDIABETIC AND CHOLESTEROL-LOWERING AGENTS
Candesartan Ciletexil (Atacand™)
Clopidogrel Bisulfate (Plavix™)
RECEPTORS AND SIGNALING
Information Flow into the Cell by Chemical Signaling.
Some Aspects of Osteoporosis
GLAUCOMA AND ANTIULCER AGENTS
AUTOIMMUNE DISEASE AND ORGAN TRANSPLANT
A Brief Survey of the Immune System
Mycophenolate Mofetil (CellCept™)
On Viruses and Viral Diseases
Zidovudine (Retrovir, AZT™)
Lopinavir + Ritonavir (Kaletra™)
ANTIMALARIAL AND ANTIPARASITIC AGENTS
Parasitic Diseases: A Focus on Malaria
Artemether + Lumefantrine (CoArtem™)
Atovaquone + Proguanil (Malarone™)
An Overview of Cancer
Ancillary Anticancer Agents
DRUGS ACTING ON THE NERVOUS SYSTEM
PAIN AND ANALGESIA
Sodium Thiopental (Sodium Pentothal™)
HYPNOTICS (INSOMNIA) AND ANTISMOKING
The Brain, Neurotransmission and Neurotransmitters
NEURODEGENERATIVE AND PSYCHIATRIC DISEASES