Categories: Organic Chemistry >> Organometallics >> Transition Metals

Modern Rhodium-Catalyzed Organic Reactions

Description

Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic.

P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments.

"Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.

Editorial Review

Transition metal catalysis stands as one of the most important topics in current chemical research and development. This intriguing field holds some surprises beyond what might be expected on the basis of the better-known palladium catalysis. Within this group, rhodium-catalyzed reactions stand out as being every bit as versatile as palladium chemistry. That the current focus in Rh-catalysis is on the construction of various carbocycles is evident from the number of remarkable ring-closure reactions listed in this book’s table of contents. Reactions such as asymmetric hydrogenation, olefin isomerization, cyclopropanation and even Rh-catalyzed hydroborations are only some of the many additional areas of note that are addressed in "Modern Rhodium-Catalyzed Reactions".

This monograph describes in detail the potential of rhodium-catalyzed transformations: each chapter and author provides an extensive overview of the current literature and/or a comprehensive mechanistic analysis. Some of the authors have managed to work through the subtleties within the development of catalyzed reactions in a highly engaging manner. The number of illustrations and suggestions related to evaluating rhodium-catalyzed reactions make this volume especially interesting for advanced students. At the same time, chemists working in research and development will be pleased that this book presents a number of exceptional transformations that are worth noting, along with its coverage of the important reactions in the area.

Thus, "Modern Rhodium-Catalyzed Reactions" continues the high standards of quality that characterize the monographs in the "Modern..." series from Wiley-VCH. This book is intended for R&D chemists as well as advanced students, as it presents an in-depth treatment of the myriad of current rhodium-catalyzed reactions in a rather fascinating manner.

Contents

Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang)
Rhodium-Catalyzed Hydroborations and Related Reactions (Brown)
Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi)
Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu)
Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton)
Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda)
Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima)
The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond)
Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou)
Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans)
Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization reactions (Jeong)
Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson)
Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender)
Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies)
Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle)
Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber)
Rhodium(II)-Catalyzed Oxidative Amination (DuBois)
Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West)
Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin)