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Modern Fluoroorganic Chemistry

Peer Kirsch

Hardcover, 308 Pages
First Edition, 2004
ISBN: 3-527-30691-9
Wiley-VCH

Description

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides.

This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

Editorial Review

More than sixty years ago, fluoroorganic chemistry substantially advanced the Manhattan Project (the construction of the first atomic bomb); these days, new reagents make simpler syntheses of fluoroorganic compounds more accessible. Modern materials and molecules with interesting physical and chemical properties, such as robust plastics (PTFE), liquid crystals, and several fluorine-containing drugs, would never have been developed without the pioneering work done in this area.

What makes fluoroorganic compounds so interesting? What synthetic methods for these compounds have become available more recently? "Modern Fluoroorganic Chemistry" answers these questions in a very informative way. From a historical overview to the newest methods and applications, this volume highlights the entire spectrum of fluoroorganic chemistry.

"Modern Fluoroorganic Chemistry" is for the chemist with an abiding interest in the field, who wants to synthesize fluorine-containing compounds. The book covers every aspect of this work, from the reagents used to introduce fluorine to the applications of the final products. "Modern Fluoroorganic Chemistry" is thus also suitable for advanced students, since it provides a good integration of knowledge in the area.

Contents

Why Organofluorine Chemistry
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
SYNTHESIS OF COMPLEX ORGANOFLUORINE COMPOUNDS
Introduction of Fluorine
Perfluoroalkylation
Special Fluorinated Groups
Syntheses with Fluorinated Building Blocks
FLUOROUS CHEMISTRY
Fluorous Biphasic Catalysis
Fluorous Synthesis and Combinatorial Chemistry
FLUOROPHARMACEUTICALS
Why Fluorinated Pharmaceuticals?
Lipophilicity
Hydrogen bonding and Electrostatic Interactions
Metabolic Stabilization
Bioisosteric Mimicking
Orthogonal Reactivity and Suicide Inhibition
LIQUID CRYSTALS FOR ACTIVE MATRIX LCDs
Calamatic Liquid Crystals: A Short Introduction
Functioning of an Active Matrix LCD
Why Fluorinated Liquid Crystals?
Fluorinated Polar Groups
Fluorinated Bridge Structures