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Chemicals >> Oxidizing Agents

Hydrogen peroxide urea adduct, UHP

Urea-hydrogen peroxide is a non-toxic, odorless crystalline solid. This adduct, which contains 35% of H2O2, sets the hydrogen peroxide free during its application.


Recent Literature


Urea-hydrogen peroxide in the presence of a catalytic amount of magnesium bromide efficiently oxidizes primary and secondary benzylic alcohols into the corresponding aromatic aldehydes and ketones.
H. J. Park, J. C. Lee, Synlett, 2009, 79-80.


Methyltrioxorhenium (MTO) catalyzes an oxidation of methyl trimethylsilyl ketene acetals with urea hydrogen peroxide to afford α-hydroxy and α-siloxy esters. On treatment with potassium fluoride, the α-hydroxy esters are obtained in high yields.
S. Stanković, J. H. Espenson, J. Org. Chem., 2000, 65, 5528-5530.


Eco-friendly laboratory procedures allow the oxidative iodination of various activated and deactivated arenes with molecular iodine, in the presence of UHP (percarbamide), a stable, strongly H-bonded, solid urea-hydrogen peroxide adduct as the oxidant.
P. Lulinski, A. Kryska, M. Sosnowski, L. Skulski, Synthesis, 2004, 441-445.


Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.


A combination of 1,1,1,3,3,3-hexafluoroispropanol (HFIP) and H2O2 enables a straightforward synthesis of N,N-disubstituted formamides from imines in very good yields via an oxidation-rearrangement sequence under smooth reaction conditions.
N. Llopis, P. Gisbert, A. Baeza, J. Org. Chem., 2020, 85, 11072-11079.


Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.


Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.


The use of urea-hydrogen peroxide and phthalic anhydride in ethyl acetate enables a metal-free, environmentally benign oxidation of substituted sulfides to their corresponding sulfones without observation of the possible sulfoxide oxidation product.
M. Lutz, M. Wenzler, I. Likthotvorik, Synthesis, 2018, 50, 2231-2234.


The use of urea-hydrogen peroxide as terminal oxidant in the presence of diphenyl diselenide as catalyst enables a highly selective catalytic oxidation of sulfides into the corresponding sulfoxides.
P. C. B. Page, B. R. Buckley, C. Elliott, Y. Chan, N. Dreyfus, F. Marken, Synlett, 2016, 27, 80-82.


Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191


A general, high yielding, and user and environmentally friendly catalytic oxidation procedure for the chemoselective oxidation of imines to nitrones is reported.
G. Soldaini, F. Cardona, A. Goti, Org. Lett., 2007, 9, 473-476.


A modified procedure for the direct synthesis of hypervalent [bis(trifluoroacetoxy)iodo]arenes avoids the use of hazardous reagents with the workup being only an aqueous extraction.
T. Keri Page, T. Wirth, Synthesis, 2006, 3080-3084.