Hydrogen peroxide urea adduct, UHP
Urea-hydrogen peroxide is a non-toxic, odorless crystalline solid. This adduct, which contains 35% of H2O2, sets the hydrogen peroxide free during its application.
Eco-friendly laboratory procedures allow the oxidative iodination of various activated and deactivated arenes with molecular iodine, in the presence of UHP (percarbamide), a stable, strongly H-bonded, solid urea-hydrogen peroxide adduct as the oxidant.
P. Lulinski, A. Kryska, M. Sosnowski, L. Skulski, Synthesis, 2004, 441-445.
Urea-hydrogen peroxide in the presence of a catalytic amount of magnesium bromide efficiently oxidizes primary and secondary benzylic alcohols into the corresponding aromatic aldehydes and ketones.
H. J. Park, J. C. Lee, Synlett, 2009, 79-80.
Urea-hydrogen peroxide adduct (UHP) is stable, inexpensive and an easily handled reagent. UHP is used in an efficient solid state oxidation of different organic molecules: hydroxylated aldehydes and ketones (to hydroxylated phenols), sulfides (to sulfoxides and sulfones), nitriles (to amides) and nitrogen heterocycles (to N-oxides).
R. S. Varma, K. P. Naicker, Org. Lett., 1999, 1, 189-191.
A general, high yielding, and user and environmentally friendly catalytic oxidation procedure for the chemoselective oxidation of imines to nitrones is reported.
G. Soldaini, F. Cardona, A. Goti, Org. Lett., 2007, 9, 473-476.
A modified procedure for the direct synthesis of hypervalent [bis(trifluoroacetoxy)iodo]arenes avoids the use of hazardous reagents with the workup being only an aqueous extraction.
T. Keri Page, T. Wirth, Synthesis, 2006, 3080-3084.