Pyridine N-oxide and derivatives
Recent Literature
An expedient and reliable method for accessing reactive α-oxo gold carbenes via
gold-catalyzed intermolecular oxidation of terminal alkynes offers a safe and
economical alternative to strategies based on diazo substrates. Its synthetic
potential is demonstrated by expedient preparation of dihydrofuran-3-ones
containing a broad range of functional groups.
L. Ye, L. Cui, G. Zhang, L. Zhang, J. Am. Chem. Soc., 2010,
132, 3258-3259.
A general synthesis of various oxetan-3-ones uses readily available propargylic
alcohols as substrates and proceeds without the exclusion of moisture or air.
The facile formation of the strained oxetane ring provides strong support for
the intermediacy of α-oxo gold carbenes. This safe and efficient generation of
gold carbenes offers an entry into α-oxo metal carbene chemistry without using
hazardous diazo ketones.
L. Ye, W. He, L. Zhang, J. Am. Chem. Soc., 2010,
132, 8550-8551.
