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Chemicals >> Reducing Agents

Rongalite, Sodium hydroxymethanesulfinate

Rongalite generates in situ sulfite anions. Therefore, sodium hydroxymethanesulfinate can be used both as a reducing agent and as a reagent for the preparation of sulfones.


Recent Literature


The use of inexpensive rongalite as a reducing agent enables a transition metal- and hydride-free chemoselective reduction of α-keto esters and α-keto amides via a radical mechanism to provide a wide range of α-hydroxy esters and α-hydroxy amides in very good yields. This mild and chemoselective method is compatible with other reducible functionalities such as halides, alkenes, amides, and nitriles.
S. Golla, H. P. Kokatla, J. Org. Chem., 2022, 87, 9915-9925.


The use of inexpensive rongalite as a reducing agent enables a transition metal- and hydride-free chemoselective reduction of α-keto esters and α-keto amides via a radical mechanism to provide a wide range of α-hydroxy esters and α-hydroxy amides in very good yields. This mild and chemoselective method is compatible with other reducible functionalities such as halides, alkenes, amides, and nitriles.
S. Golla, H. P. Kokatla, J. Org. Chem., 2022, 87, 9915-9925.


Rongalite promotes a smoth, one-pot synthesis of aryl alkyl sulfides from disulfides and alkyl halides at room temperature. This protocol is metal-free, strong-base-free, and offers mild reaction conditions, operational simplicity, short reaction times and high yields of products.
R.-y. Tang, P. Zhong, Q.-l. Lin, Synthesis, 2007, 85-91.