Further Information
Literature
Favorskii Reaction
The rearrangement of cyclopropanones, often obtained as intermediates from the base-catalyzed reaction of α-halo ketones, leading to carboxylic acids and derivatives.
Mechanism of the Favorskii Reaction
Esters are obtained if alkoxide bases are used:
A direct conversion from α-halo ketones is possible:
Ring-contraction:
Recent Literature
Nickel-Catalyzed Favorskii-Type Rearrangement of Cyclobutanone Oxime Esters
to Cyclopropanecarbonitriles
B. Shuai, P. Fang, T.-S. Mei, Synlett, 2021,
32,
1637-1641.
Halocycloalkenones as Diels-Alder Dienophiles. Applications to Generating
Useful Structural Patterns
A. G. Ross, S. D. Townsend, S. J. Danishefsky, J. Org. Chem., 2013,
78, 204-210.