Further Information
Literature
Related Reactions
Gewald Reaction
Synthesis of indoles
Fischer Indole Synthesis
The conversion of aryl hydrazones to indoles; requires elevated temperatures and the addition of Brønsted or Lewis acids. Some interesting enhancements have been published recently; for example a milder conversion when N-trifluoroacetyl enehydrazines are used as substrates. (abstract).
Mechanism of the Fischer Indole Synthesis
Recent Literature
Aryl Hydrazide beyond as Surrogate of Aryl Hydrazine in the Fischer
Indolization: The Synthesis of N-Cbz-indoles, N-Cbz-carbazoles,
and N,N'-Bis-Cbz-pyrrolo[2,3-f]indoles
I.-K. Park, S.-E. Suh, B.-Y. Lim, C.-G. Cho, Org. Lett., 2009,
11, 5454-5456.
Efficient Preparation of Polyfunctional Indoles via a Zinc Organometallic
Variation of the Fischer Indole Synthesis
Z..-G. Zhang, B. A. Haag, J.-S. Li, P. Knochel, Synthesis, 2011,
23-29.
A Palladium-Catalyzed Strategy for the Preparation of Indoles: A Novel Entry
into the Fischer Indole Synthesis
S. Wagaw, B. H. Yang, S. L. Buchwald, J. Am. Chem. Soc., 1998,
120, 6621-6622.
The Benzyne Fischer-Indole Reaction
D. McAusland, S. Seo, D. G. Pintori, J. Finlayson, M. F. Greaney, Org. Lett., 2011,
13, 3667-3669.
Thermal cyclization of N-trifluoracetyl enehydrazines under mild
conditions: A novel entry into the Fischer indole synthesis
O. Miyata, Y. Kimura, K. Muroya, H. Hiramatsu, T.
Naito, Tetrahedron Lett., 1999, 40, 3601-3604.
