Further Information
Literature
Related Reactions
Gewald Reaction
Synthesis of indoles
Fischer Indole Synthesis
The conversion of aryl hydrazones to indoles; requires elevated temperatures and the addition of Brønsted or Lewis acids. Some interesting enhancements have been published recently; for example a milder conversion when N-trifluoroacetyl enehydrazines are used as substrates. (abstract).
Mechanism of the Fischer Indole Synthesis
Recent Literature
A Palladium-Catalyzed Strategy for the Preparation of Indoles: A Novel Entry
into the Fischer Indole Synthesis
S. Wagaw, B. H. Yang, S. L. Buchwald, J. Am. Chem. Soc., 1998,
120, 6621-6622..
Thermal cyclization of N-trifluoracetyl enehydrazines under mild
conditions: A novel entry into the Fischer indole synthesis
O. Miyata, Y. Kimura, K. Muroya, H. Hiramatsu, T.
Naito, Tetrahedron Lett., 1999, 40, 3601-3604.
