Further Information
Literature
Related Reactions
Synthesis of
quinolines
Friedlaender Synthesis
The starting materials for this quinoline synthesis are o-aminoaryl aldehydes or ketones and a ketone possessing an α-methylene group. After an initial amino-ketone condensation, the intermediate undergoes base- or acid-catalyzed cyclocondensation to produce a quinoline derivative.
Mechanism
Recent Literature
Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of
microwave irradiation versus conventional heating
C.-S. Jia, Z. Zhang, S.-J. Tu, G.-W. Wang, Org. Biomol. Chem., 2006, 4, 104-110.
Molecular iodine: a highly efficient catalyst in the synthesis of quinolines via
Friedländer annulation
J. Wu, H.-G. Xia, K. Gao, Org. Biomol. Chem., 2006, 4, 126-129.
Silver Phosphotungstate: A Novel and Recyclable Heteropoly Acid for
Friedländer Quinoline Synthesis
J. S. Yadav, B. V. S. Reddy, P. Sreedhar, R. S. Rao, K. Nagaiah, Synthesis,
2004, 2381-2385.
Efficient and Rapid Friedlander Synthesis of Functionalized Quinolines
Catalyzed by Neodymium(III) Nitrate Hexahydrate
R. Varala, R. Enugala, S. R. Adapa,
Synthesis, 2006, 3825-3830.
Ionic Liquid-Promoted Regiospecific Friedlander Annulation: Novel Synthesis
of Quinolines and Fused Polycyclic Quinolines
S. S. Palimkar, S. A. Siddiqui, T. Daniel, R. J. Lahoti, J. V. Srinivasan,
J. Org. Chem., 2003, 68, 9371-9378.
Highly Regioselective Friedländer Annulations with Unmodified Ketones
Employing Novel Amine Catalysts: Syntheses of 2-Substituted Quinolines,
1,8-Naphthyridines, and Related Heterocycles
P. G. Dormer, K. K. Eng, R. N. Farr, G. H. Humphrey,
J. C. McWilliams, P. J. Reider, J. W. Sager, R. P. Volante, J. Org. Chem.,
2003, 68, 467-477.
