Pinner Reaction

The Pinner Reaction is the partial solvolysis of a nitrile to yield an iminoether. Treatment of the nitrile with gaseous HCl in a mixture of anhydrous chloroform and an alcohol produces the imino ether hydrochloride. These salts are known as Pinner Salts, and may react further with various nucleophiles.

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Mechanism of the Pinner Reaction

Recent Literature

Preparation and Utility of Trihaloethyl Imidates: Useful Reagents for the Synthesis of Amidines
S. Caron, L. Wei, J. Douville, A. Ghosh, J. Org. Chem., 2010, 75, 945-947.