Wenker-Synthesis

This reaction sequence allows the preparation of aziridines from 1,2-amino alcohols.

---

Mechanism of the Wenker Synthesis

After preparation of sulphonate salt, a second deprotonation step effects the ring closure:

---

Recent Literature

Synthesis of N-H vinylaziridines: a comparative study
B. Olofsson, R. Wijtmans, P. Somfai, Tetrahedron, 2002, 58, 5979-5982.

Short and Efficient Synthesis of Optically Active N-Tosyl Aziridines from 2-Amino Alcohols
L. W. Bieber, M. C. F. de Araujo, Molecules, 2002, 7, 902.