Protecting Groups
Stability data for the most frequently used protective groups, protection and deprotection methods
Functional Groups:
| Amino | 9-Fluorenylmethyl carbamate (Fmoc-NRR') | t-Butyl carbamate (Boc-NRR') |
| >> Stability |
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| Benzyl carbamate (Z-NRR', Cbz-NRR') | Acetamide | Trifluoroacetamide |
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| Phthalimide | Benzylamine (Bn-NRR') | Triphenylmethylamine (Tr-NRR') |
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| Benzylideneamine | p-Toluenesulfonamide (Ts-NRR') | |
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| Carbonyl | Dimethyl acetal | 1,3-Dioxane |
| >> Stability |
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| 1,3-Dithiane | N,N-Dimethylhydrazone | |
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| Carboxyl | Methyl ester | t-Butyl ester |
| >> Stability |  |
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| Benzyl ester | S-t-Butyl ester | 2-Alkyl-1,3-oxazoline |
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| Hydroxyl | Methoxymethyl ether (MOM-OR) | Tetrahydropyranyl ether (THP-OR) |
| >> Stability |  |
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| t-Butyl ether | Allyl ether | Benzyl ether (Bn-OR) |
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| t-Butyldimethylsilyl ether (TBDMS-OR) | t-Butyldiphenylsilyl ether (TBDPS-OR) | Acetic acid ester |
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| Pivalic acid ester | Benzoic acid ester | |
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| 1,2-; 1,3-Diols | Acetonide | Benzylidene acetal |
| >> Stability |  |
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