Categories: C-Br Bond Formation >
Synthesis of benzyl bromides
Recent Literature
Silicaphosphine (Silphos), [P(Cl)3−n(SiO2)n] is a new
heterogeneous reagent that converts alcohols and thiols to their corresponding
bromides and iodides in the presence of molecular halogen in refluxing CH3CN
in high to quantitative yields. Separation of the Silphos oxide byproduct can be
achieved by a simple filtration.
N. Iranpoor, H. Firouzabadi, A. Jamalian, F. Kazemi, Tetrahedron, 2005,
61, 5699-5704.
An efficient conversion of alcohols and β-amino alcohols to the corresponding
chlorides can be carried out at room temperature in methylene
chloride, using 2,4,6-trichloro[1,3,5]triazine and N,N-dimethyl formamide.
Addition of NaBr allows the synthesis of bromides. Optically active carbinols
react under inversion.
L. de Luca, G. Giacomelli, A. Porcheddu, Org. Lett., 2002,
4, 553-555.
