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Categories: C-C Bond Formation > Arenes, Cyclic Compounds > Benzocycloalkenones

Synthesis of benzocyclobutenones

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A palladium-catalyzed intramolecular acylation of aldehydes with aryl bromides via C-H functionalization is distinguished by a remarkable functional group tolerance and hence enables the synthesis of various highly functionalized benzocyclobutenones from simple and easily accessible precursors.
P. Álvarez-Bercedo, A. Flores-Gaspar, A. Correa, R. Martin, J. Am. Chem. Soc., 2010, 132, 466-467.